CFS/ME and Exercise

[Cloud]

http://www.suite101.com/content/cfsme-and-exercise-a85883


"CFS/ME results in increased levels of the receptors for IL-6 and TNF"

 

[Wonko]

They appear to say that IL6 is good if as a result of intense exercise but as pwME never engage in intense activity it's bad because without intense exercise it's an inflamitory which can cause muscle wasting amongst all the other wonderful side effects of inflamation in pwME.

Or have I got that wrong?

 

[Cloud]

They appear to say that IL6 is good if as a result of intense exercise but as pwME never engage in intense activity it's bad because without intense exercise it's an inflamitory which can cause muscle wasting amongst all the other wonderful side effects of inflamation in pwME.

Or have I got that wrong?

Hey Wonko,

I understood it to say that the increased levels of IL6 and TNF in ME/CFS causes the development of more receptors for these cytokines, which may perpetuate the problem by encouraging an even greater release of IL6 and TNF, in particular, with exertion. But, I may need to read it more closely as well.

I have always favored the idea of "Cytokine Storm" being primary cause of my symptoms, especially PEM. I had never read about this idea of growing additional receptors to meet the need of the increased levels of cytokines. It just made a lot of sense to me. And it seems a logical direction for the pursuit of Tx ideas.

 

[Wonko]

yep, definately time to read more stuff I think, anything that will give me more of a handle on whats going on exercise wise is useful

in theory if I read enough some of it may stick, I may even remember what was actually written as opposed to what I thought was lol

thanks for the info Cloud

 

[Tammie]

so this would mean that exercise is also bad for MCS? cytokines are involved in that, too