ixchelkali
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I was interested in his summary of the disease progression in the macaque monkey study. I read about that when the study came out, but this presentation was easier to understand. Especially interesting was that at first XMRV was found in white blood cells, specifically CD4+ T cells and K cells (K cells??? I've got to look that up). Immediately after, it goes to the prostate and the brain, lymphoid organs, spleen, bone marrow, small and large intestine, lung and pancreas.
At 5 months, the prostate is clear, but stromal cells are infected. XMRV is then found in lymphoid organs, large & small intestines, lung (macrophages), testis, seminal vesicles, vagina & cervix (epithelium).
I'm not sure how this relates to his comment speculating that in prostate cancer patients, the virus persists in those with poor antiviral defenses. It sounds like in the macaques, the infection persisted in all of them, but shifted locations. I don't remember that the macaques were low in antiviral defenses.
At 5 months, the prostate is clear, but stromal cells are infected. XMRV is then found in lymphoid organs, large & small intestines, lung (macrophages), testis, seminal vesicles, vagina & cervix (epithelium).
I'm not sure how this relates to his comment speculating that in prostate cancer patients, the virus persists in those with poor antiviral defenses. It sounds like in the macaques, the infection persisted in all of them, but shifted locations. I don't remember that the macaques were low in antiviral defenses.