Treating depression at the microbiome level (diet, probiotics, etc)

Blog entry posted by Lassesen, Mar 10, 2018.

I have done a few posts on depression over the years
A friend asked me to revisit it, especially now that I have a recommendation program working.

Depression and the Microbiome – PubMed
From The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option [2017].

  • over-presentation of the orders of Bacteroidales and
  • under-presentation of the orders of Lachnospiraceae,
  • Higher level of Oscillibacter and Alistipes had higher depression
  • increased levels of Enterobacteriaceae and Alistipes
  • reduced levels of Faecalibacterium
Altered fecal microbiota composition in patients with major depressive disorder [2015]. adds that “Bacterial diversity was significantly higher ” and also reported additionally (for two types of depression):

  • higher Bacteroidaceae,
  • higher Butyricimonas,
  • higher Clostridium XlVb
  • higher Enterobacteriaceae,
  • higher Parabacteroides,
  • higher Phascolarctobacterium,
  • higher Porphyromonadaceae,
  • higher Rikenellaceae
  • higher Roseburia
  • higher Acidaminococcaceae,
  • higher Flavonifractor,
  • higher Proteobacteria
  • lower Actinobacteria
  • lower Fusobacteria,
  • lower Ruminococcaceae,
  • lower Veillonellaceae
  • lower Lachnospiraceae,
  • lower Dialister,
  • lower Escherichia/Shigella,
  • lower Firmicutes,
  • lower Haemophilus,
  • lower Prevotella,
  • lower Ruminococcus
Additionally, Isovaleric acid in stool correlates with human depression.[2016] hence isovaleric acid producing bacteria appear to be another facet.

Isovaleric acid producing bacteria includes [ref]:

  • Bacillus subtilis natto
  • Prevotella
  • Porphyromonas
Automated Analysis of your Ubiome
After you logged on to This Depression link will show your results against the above list. As a reminder, there are other comparisons available:

The result is a report such as shown below


At the bottom is a link to recommendations for the ‘Match’ items above only. That is, the recommendations are specific to the depression symptom.


For the first one on the list, I did a google and found lots of pages saying that pomegranate helps depression!

Imagine that! With the microbiome approach, you are getting truly individualized suggestions and not proforma suggestions.
pamojja likes this.

About the Author

CFS Remissions Curated Posts
  1. Lassesen
    In a significant percentage of people it should. There can be multiple causes (including DNA).
  2. Lassesen
    In a significant percentage of people it should. There can be multiple causes (including DNA).
  3. 1gooddog
    Does this defeat the cause of depression. The disease itself?