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List of international positive XMRV studies - published and unpublished papers

Blog entry posted by Bob, Nov 11, 2010.

I've collated a list of the most significant, published and unpublished, international positive XMRV studies that I know about, including the European and Japanese research studies ... along with a very brief summary of each of them.
I've included the links to the published papers, or to the unpublished abstracts, or to other sources the information if I haven't seen the actual papers.
If anyone knows of any more sources of info on any of these, or has links to the actual papers, then please could you let me know so I can add the info? Thank you.
There are other positive XMRV studies as well, but I have only included what I think are the most significant positive studies. (The studies I've included are testing people for XMRV, while the other studies are researching the nature of XMRV itself.)
Suggestions to include other studies will be gratefully received.


Initial discovery of XMRV in prostate cancer patients

XMRV was first discovered in 2006 in prostate cancer patients. Here is the published research paper...
"Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant." 31st March 2006. by Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
http://www.ncbi.nlm.nih.gov/pubmed/16609730?dopt=Abstract&holding=f1000,f1000m,isrctn


XMRV first discovered in ME/CFS patients

Judy Mikovits' paper was published in Science in Oct 2009.
XMRV detected in 67% of ME patients and 3.7% of healthy controls.
http://www.sciencemag.org/cgi/content/abstract/1179052


FDA/NIH study published in August 2010

Alter and Lo's FDA/NIH paper published in PNAS.
MLV-related viral sequences detected in 86.5% of ME/CFS patients and 6.8% of healthy controls.
http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf html


The WPI's unpublished UK study:

Not yet published, but reported to be about 80% positive for XMRV in UK ME patients, and 6-8% positive in the UK blood supply.
See info from the CFIDS Association of America's website, here:
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits


The WPI's unpublished study on families

Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
"Detection of infectious XMRV in the peripheral blood of children"
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits


Dr Cheney and Dr Bell - unpublished studies

Separate unpublished studies in the USA, using patients from Dr Cheney's and Dr Bell's clinics, have confirmed high rates of XMRV infection in ME patients.

Dr Cheney:
74.5% of consecutive ME patients, who went to the Cheney Clinic, tested positive for XMRV.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

Dr Bell:
80% of 10 patients currently meeting Fukuda criteria tested positive for MLV-related sequences and 1% of healthy controls.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.cfids.org/xmrv/wrkshp-report.pdf


Japan (publication status unknown to me)
XMRV found in 1.7% of random healthy blood donor samples from the blood supply in Japan, testing for antibodies only. (This was a study of blood bank samples and prostate cancer patients, not ME patients.)
http://www.diagnosesupport.com/heal...ted-virus-in&catid=132:xmrv-research&Itemid=8


Germany (publication status unknown to me)
XMRV found in respiratory secretions in 3.2% of healthy control samples (study not carried out on ME patients).
Respiratory samples taken from patients with respiratory tract infection and healthy persons.
http://www.cdc.gov/EID/content/16/6/1000.htm
http://www.cdc.gov/EID/content/16/6/1000-T.htm


Norway (publication status unknown to me)
62% of patients tested positive for XMRV at the Lillestrom Health Clinic, using the VIPdx lab.
http://www.prohealth.com/library/showarticle.cfm?libid=15684

The Lillestrom Health Clinic tested 80 patients and 50 were tested positive by either culture or serology test a total of 62%. The tests were done in cooperation with VIPdx labs in the USA.

More information about these results will be given on the 28th of November 2010 in Oslo at the XMRV/MLV seminar with Dr. Judy Mikovits... See this link for more details of the November Oslo XMRV seminar:
http://esme-eu.com/home/xmrv-mlv-se...f-november-2010-oslo-norway-article423-6.html

In November 2010, the Lillestrom Health Clinic will launch a large international research project on Human Gammaretrovirus and ME.


Belgium (publication status unknown to me)
Study led by Professor De Meirleir.
Researchers at the Vrije Universiteit Brussel (VUB) and the Belgian company biotech RED Laboratories "are able to identify a new retrovirus in patients with chronic fatigue syndrome."
http://translate.google.co.il/trans...la-fatigue-chronique&sl=fr&tl=en&hl=&ie=UTF-8
http://www.forums.aboutmecfs.org/attachment.php?attachmentid=3848&d=1284150125
http://www.forums.aboutmecfs.org/showthread.php?7124-Meirleir-confirms-XMRV-findings-in-Europe
http://www.nieuws.be/nieuws/VUB-ond...chronisch_vermoeidheidssyndroom_6a743703.aspx
http://regist2.virology-education.com/abstractbook/2010_8.pdf


Spain (publication status unknown to me)
Pilot study by J Blanco et al:
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.forums.aboutmecfs.org/sh...-Spanish-XMRV-studies&highlight=spanish study

Spain (progress of study unknown to me)
Hospital Vall d'Hebron in Barcelona:
http://www.abc.es/agencias/noticia.asp?noticia=574407
http://www.prohealth.com/library/showarticle.cfm?libid=15703

[It's uncertain that the facts have been reported correctly in this case - see discussion]

_____________________________________________________________________________________________


List of some of the ongoing research:

Harvey Alter (discovered the HEP C virus), working for the FDA investigating MLV-related viruses in ME/CFS patients. He is looking for antibodies, and will be isolating the virus, and sequencing the genome of the PMRV's which he found.

W. Ian Lipkin (internationally recognized for his work with West Nile virus and SARS) working for US government health agencies to investigate XMRV in ME patients.
http://blogs.wsj.com/health/2010/09...atest-xmrv-study/?KEYWORDS=amy dockser marcus

Frank and Sandra Ruscetti, working at the NCI (National Cancer Institute) carrying out research into XMRV and its effect on the immune system.
http://ccr.cancer.gov/staff/staff.asp?staffid=270

Dr Singh, carrying out some complex studies on XMRV.
http://www.forums.aboutmecfs.org/entry.php?585-Report-From-the-OFFER-2010-Conference

Judy Mikovits looking at a link between immune abnormalities and XMRV, XMRV in autism and atypical MS. Working on a UK study reportedly showing XMRV in about 80% of ME patients.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits

The US Blood Working Group is working towards standardising the methodology for detecting XMRV, and then they will do larger scale studies looking for XMRV in the population.
http://www.cfids.org/cfidslink/2009/120203.asp
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
http://blogs.wsj.com/health/2010/07...e-to-hear-about-xmrv-working-groups-research/
More info about upcoming XMRV studies:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx


Info about published, unpublished, proposed and ongoing research studies

Details (on Phoenix Rising website and forum) of proposed, upcoming, incomplete and unpublished research studies:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx

Details of all the published XMRV studies to date, including the two published positive USA studies, and all the negative published studies (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/data-comparison-082410.pdf

Details of unpublished XMRV studies presented at the 1st International Conference on XMRV (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

Abstract Book - 1st International Conference on XMRV
Collated research papers presented at the 1st International Conference on XMRV (A PDF document):
http://regist2.virology-education.com/abstractbook/2010_8.pdf


Recent articles regarding the state of play for XMRV research:

World Class Virus Hunter To Head Up the Latest XMRV Study.
http://blogs.wsj.com/health/2010/09...atest-xmrv-study/?KEYWORDS=amy dockser marcus

XMRV On Everyones Mind at a Chronic Fatigue Syndrome Meeting.
http://blogs.wsj.com/health/2010/10...syndrome-meeting/?KEYWORDS=amy dockser marcus

Recent news and progress:
http://www.forums.aboutmecfs.org/co...-in-the-balance-A-Tale-of-Two-Conferences-CFS

Ongoing and proposed XMRV research:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx


1st International Conference on XMRV

There is a selection of abstracts of XMRV studies presented the 1st International Conference on XMRV here:

"Abstract Book" - Collated research papers presented at the 1st International Conference on XMRV (A PDF document):
http://regist2.virology-education.com/abstractbook/2010_8.pdf

Details of unpublished XMRV studies presented at the 1st International Conference on XMRV (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
  1. Bob
    Hi Bob

    Great work/contribution! I have been looking for a list like this to cross reference against my own so a very big thank you for your efforts.

    Hi insearchof,
    Glad you've found it helpful...
    I haven't been keeping it up-to-date with new developments, so recent developments are not listed on there.
    Bob
  2. insearchof
    Hi Bob

    Great work/contribution! I have been looking for a list like this to cross reference against my own so a very big thank you for your efforts.
  3. Bob
    The CFIDS Association chart is excelent. I have wondered about making a similar chart in a wiki article to list all the published (and separately, the reported unpublished or conference presentations), XMRV studies, regardless of the population/patient group. I'd like the chart to have more explicit details on the sequences tested, methodological differences so any differences between positive and negative studies might be more clear.

    Oh and a list of all the review articles.

    Hi Snow Leopard,

    That's a great idea... It will be difficult to compile the details of the European studies though... I can't determine if any of these European papers are published or unpublished, and I can't find any completed research papers, although there are one or two abstracts available. Also, it seems that some of the reported 'facts', associated with the European studies, are incorrect, such as the details of one of the Spanish studies, which maybe hasn't even been started yet, as far as I can tell, but was reported to have found XMRV in 70% of ME patients... It seems that the facts got lost in translation.

    But your wiki idea is still a good idea... And if you could keep it up-to-date, or we could keep it up-to-date as a forum community project, then that would be a really helpful resource.
    I haven't come across any other listings of these European studies anywhere.
  4. Snow Leopard
    The CFIDS Association chart is excelent. I have wondered about making a similar chart in a wiki article to list all the published (and separately, the reported unpublished or conference presentations), XMRV studies, regardless of the population/patient group. I'd like the chart to have more explicit details on the sequences tested, methodological differences so any differences between positive and negative studies might be more clear.

    Oh and a list of all the review articles.
  5. Rita
    Vall dHebron is a hospital that made a workshop about the importance of viruses in CFS few days ago(with D.Montoya, among others),thats why they were in press.They are specilized in patients SFC
    Now they want to begin a study with another hospital specialized in CFS, Hospital Clinic, and Can Ruti,specialized in Aids, to look for XMRV. All are in Barcelone.
    Probably another doctor in Barcelona, Dr.Ferran, is beginning a study with Carlos III Hospital (Madrid),but dont know anything else.
    If I read something sure Ill tell you.
    Of course , all studies will be about XMRV in CFS patients.
  6. Bob
    Thanks for that Rita...
    I hadn't heard anyone say that before...

    There's only one article that has info about it... So it must be badly reported...
    Are you saying that they haven't done any research yet?

    I've left the links on there for now, but deleted my quote, until i find further info about it.
  7. Rita
    Im tired to say that the first Spanish study is not true.
    Vall dHebron never studied the XMRV till now.Dont know if its the fault of the journalist.