Australian and New Zealand Clinical Trial on improving symptoms by shifting microbiome

Blog entry posted by Lassesen, Feb 8, 2018.

The title sounded grander than what it actually contained

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons [2018] – Full text

Results support the notion that specific microorganisms interact with some ME/CFS symptoms and offer promise for the therapeutic potential of targeting gut dysbiosis in this population. Streptococcus spp. are not the primary or sole producers of d-lactate. Further investigation of lactate concentrations are needed to elucidate any role of d-lactate in this population. Concurrent microbial shifts that may be associated with clinical improvement (i.e., increased Bacteroides and Bifidobacterium or decreased Clostridium in males) invite enquiry into alternative strategies for individualised treatment.”

The role of staphylococcus was known in 2015, and I did a post on it in January 2016. The d-lactic aspect, I posted about in 2015 in this post Approaches to D-Lactic Acidosis.

What they appear to miss was streptococcus causing histamine issues, see this 2014 post, Histamine intolerance – a possible CFS mechanism.

Their Protocol?
Alternative weeks of:



400 mg/b.d.


Pro4-50 d-Lactate Free Multistrain

1 tablet b.d.

It was interesting to note that there was no attempt to reduce streptoccocus by diet etc. The suggestions from existing literature are on the ubiome analysis site. A small example:

The choice of Erythromycin is a bit of a puzzle, because of increasing resistance of many streptoccocus to this antibiotic. I pointed this out in my 2017 post, Reducing Streptococcus genus where I cited this study

Phenotypic and genotypic characterization of antibiotic resistance of methicillin-resistant Staphylococcus aureus isolated from hospital food. [2017]

  • MRSA strains harbored the highest prevalence of resistance against penicillin (100%), ceftaroline (100%), tetracycline (100%), erythromycin (89.18%) and trimethoprim-sulfamethoxazole
Symptoms to Bacteria Association
They did find that shifts of bacteria did result in improvement of symptoms — which is exactly what I expected to see.
Bottom Line
This study supports and illustrates the basics of my model. If you are not too brain fogged, it is an interesting read. Their approach seems a little simplistic, but they did obtain good results.
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